Magnetic nanoparticles as a platform for delivery of the photosensitizer methylene blue to HCT116 tumor cells
- Authors: Nguyen M.T.1, Markova A.A.1, Batchaeva B.B.1, Gorobets M.G.1, Toroptseva A.V.1, Motyakin M.V.1, Abdullina M.I.1, Bychkova A.V.1
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 44, No 3 (2025)
- Pages: 106-110
- Section: ХИМИЧЕСКАЯ ФИЗИКА НАНОМАТЕРИАЛОВ
- URL: https://cardiosomatics.orscience.ru/0207-401X/article/view/679474
- DOI: https://doi.org/10.31857/S0207401X25030119
- ID: 679474
Cite item
Abstract
Hybrid nanosystems based on magnetic iron oxide nanoparticles (IONPs) and human serum albumin (HSA), containing methylene blue (MB) as a model photosensitizer, have been synthesized. The resulting HSA@IONP nanosystems were characterized for size and composition using UV/visible spectrophotometry (particularly, using the Bradford method), dynamic light scattering, and electron magnetic resonance. A study of the dark and photoinduced cytotoxicity of MB, IONP, HSA@IONP, MB–IONP, MB–(HSA@IONP) on of human colon adenocarcinoma HCT116 cells was carried out. Under the experimental conditions, the difference between the dark and light-induced cytotoxicity of nanosystems on cells was significantly enhanced when the photosensitizer was immobilized on the surface of the carrier particles compared to free photosensitizer in equivalent concentrations.
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About the authors
M. T. Nguyen
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
A. A. Markova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
B. B. Batchaeva
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
M. G. Gorobets
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
A. V. Toroptseva
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
M. V. Motyakin
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
M. I. Abdullina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
A. V. Bychkova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: anna.v.bychkova@gmail.com
Russian Federation, Moscow
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