Antiviral Potential of Marine Bacteria Polysaccharides

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Intensive population interactions between components of plankton and virioplankton of the World Ocean have formed ancient and, at the same time, versatile mechanisms for protecting marine bacteria and archaea from the effects of ocean viruses on them. One of such mechanisms is exopolysaccharides, which are secreted by marine prokaryotes to interact with surface proteins of viral particles and prevent the binding of viral peplomers to receptors of potential target cells. Therefore, antiviral drugs with a wide spectrum of actions, exhibiting also the ability to modulate intercellular interactions, are found in large numbers among exopolysaccharides of marine bacteria. The review analyzes the modern views on exopolysaccharides of marine bacteria, their antiviral potential, and antioxidant and immunomodulatory activity. A brief description of the structural, physical, and chemical properties of such compounds is given and the main mechanisms of antiviral activity of the best-known representatives of this class of organic polymers are disclosed. Exopolysaccharides of marine bacteria are shown to be a promising and extremely rich source of antiviral medicinal substances.

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T. Kuznetsova

Somov Research Institute of Epidemiology and Microbiology, Federal Service the Oversight of Consumer Protection and Welfare (Rospotrebnadzor)

编辑信件的主要联系方式.
Email: takuznets@mail.ru
ORCID iD: 0000-0002-4315-6959
俄罗斯联邦, Vladivostok

N. Besednova

Somov Research Institute of Epidemiology and Microbiology, Federal Service the Oversight of Consumer Protection and Welfare (Rospotrebnadzor)

Email: takuznets@mail.ru
俄罗斯联邦, Vladivostok

T. Zaporozhets

Somov Research Institute of Epidemiology and Microbiology, Federal Service the Oversight of Consumer Protection and Welfare (Rospotrebnadzor)

Email: takuznets@mail.ru
ORCID iD: 0000-0002-8879-8496
俄罗斯联邦, Vladivostok

M. Kokoulin

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences

Email: takuznets@mail.ru
ORCID iD: 0000-0003-2245-6802
俄罗斯联邦, Vladivostok

Yu. Khotimchenko

Far Eastern Federal University; Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences

Email: takuznets@mail.ru
ORCID iD: 0000-0002-6979-1934
俄罗斯联邦, Vladivostok; Vladivostok

M. Shchelkanov

Somov Research Institute of Epidemiology and Microbiology, Federal Service the Oversight of Consumer Protection and Welfare (Rospotrebnadzor); Far Eastern Federal University; Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences

Email: takuznets@mail.ru
ORCID iD: 0000-0001-8610-7623
俄罗斯联邦, Vladivostok; Vladivostok; Vladivostok

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