


Vol 73, No 1 (2023)
ОБЗОРЫ И ТЕОРЕТИЧЕСКИЕ СТАТЬИ
SECOND-ORDER VISUAL MECHANISMS: REVIEW OF RESEARCH
Abstract
The review is devoted to the analysis of studies aimed at studying second-order visual filters as a mechanism for preattentive grouping of local visual information by striate neurons (first-order filters). The development of ideas about possible mechanisms for combining primary visual features is analyzed, with the emphasis on studies of the properties of second-order filters. The questions of spatial organization and principles of interaction of filters of the first and second orders are considered. The results indicating the multichannel nature of the pooling mechanism and possible relationship between the frequency and orientation settings of the filters of the first and second order are described. A model for organizing filters of the second order is presented, possible neurophysiological correlates of these mechanisms are analyzed, role of the second-order mechanisms in visual perception is considered.



ФИЗИОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ (КОГНИТИВНОЙ) ДЕЯТЕЛЬНОСТИ ЧЕЛОВЕКА
THETA AND ALPHA BANDS SPECTRAL POWER OF RESTING-STATE EEG IN GROUPS WITH DIFFERENT EFFICIENCY OF JOINT ACTIVITY IN DIADS
Abstract
The aim of the study was to compare the spectral characteristics of theta and alpha frequency bands of the resting-state EEG between groups of subjects with different performance of subsequent joint sensorimotor activity in dyads. The study involved 26 men who, in 13 pairs, performed “Columns” trainings with biofeedback from EMG signals from the flexor muscles of the leading hand. According to their performance, the subjects of each pair were assigned to one of 2 groups: “winners” or “losers”. A higher spectral power of the theta rhythm of the EEG with closed eyes was found in the group of “losers” in comparison with the group of “winners” in the frontal, central and temporal zones of the cortex. The “winners” showed a higher level of spectral power of the EEG alpha rhythm with the eyes closed, especially in the alpha-2 frequency range in all 8 zones. The effectiveness of individual and joint training correlated negatively with the theta power and positively with the power of the EEG alpha rhythms in the closed-eyed state.



ASSOCIATION OF THE ZNF804A rs1344706 GENE POLYMORPHISM WITH THE INDUCED EEG RHYTHMS IN VISUAL PERCEPTION OF THE VERBAL STIMULI IN HEALTHY SUBJECTS AND IN SCHIZOPHRENIA
Abstract
We studied the relationship between the ZNF804A rs1344706 gene polymorphism and the parameters of event-related synchronization/desynchronization of EEG rhythms in visual perception of semantic and meaningless verbal information in patients with schizophrenia and schizophrenia spectrum disorders (n = 93) and mentally healthy subjects (n = 93). When reading verbal information regardless of psychiatric status, the theta rhythm synchronization was less pronounced in subjects with the AA genotype than in carriers of allele C. In healthy subjects, the carriers of the AA genotype, in comparison with carriers of allele C, the synchronization of theta rhythm in the posterior cortical areas of the left hemisphere was reduced, and there were no differences in the synchronization of gamma and desynchronization of mu rhythms when perceiving semantic and nonsensical verbal information. In patients with genotype AA, compared with carriers of allele C, the desynchronization of mu rhythm was smaller, which correlated with the severity of poverty of speech on the PANSS scale. The study results indicate a modulating effect of the rs1344706 polymorphism of the ZNF804A gene on the neurophysiological characteristics of the reading process and its contribution to the variability of clinically expressed language disorders.



EVALUATION OF EFFICIENCY OF USING OF BRAIN-COMPUTER INTERFACE IN LEARNING IMAGINATION OF MOVEMENTS OF UPPER AND LOWER LIMBS
Abstract
The effectiveness of brain-computer interface (BCI) control and the success of imagination of movement of the upper and lower extremities were evaluated by the accuracy of recognition of EEG signals (classification accuracy) when imagining movements of the hands, feet and locomotion during 10-day training of 10 volunteers. Averaged data of all the volunteers revealed, that, on the first day of training, the classification accuracy is higher when imagining locomotion than foot movements, on the second day – hands than locomotion, on the fifth day – feet than hands. The average values of classification accuracy when imagining movements of the hands and feet increase by the 3rd day of training, further changes are specific depending on which movement is imagined. When learning the imagination of locomotion, the accuracy of classification does not significantly change. An assessment of the dynamics of individual changes in the accuracy of classification according to linear trends showed that in three participants, training led to an increase in the accuracy of classification (of the hand movements and locomotion – in one subject, of feet – in two subjects); in other three participants – to decrease (of the movements of the hands and locomotion – in one subject, of the locomotion – in the second subject, of feet – in the third). The four participants, as well as the sample average, had no significant changes. The results are discussed in terms of changes in the activity of brain structures during learning and depending on the type of imaginary movements.



ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬ
COLOR PERCEPTION AND ITS CODING IN SIMIAN NEOCORTEX
Abstract
Perception of color by human and nonhuman primates is a complex problem, which is studied not only by neurophysiology, but also by neighboring fields of science such as psychophysiology, psycholinguistics, and even philosophy. With neurophysiology as a starting point, I review contributions of adjacent fields in understanding of the primates’ color space encoding. All known at the moment neurophysiologic mechanisms of color perception by primates are reviewed and a hypothetical way of color stimuli processing is proposed, suggesting at a final stage involvement of conceptual (gnostic) neurons encoding only colors of visual stimuli.



WALKING OF A DECEREBRATE CAT AT SIMULTANEOUSLY DIFFERENT SPEEDS ON A SPLIT TREDBAN
Abstract
The decisive role of sensory input in the initiation and modulation of locomotion has been shown repeatedly. One way to explore this input is the “split” treadmill paradigm. In the present study, a comparative analysis of the walking of a decerebrate cat on a split treadmill was carried out, the belts of which moved not only at different speeds (differed by 3 times), but also in different directions (forward and backward). The reciprocal work of two limbs, as well as the flexor and extensor muscles of each limb, is shown in such a locomotor mode. Two main walking strategies were identified: in response to one step of the limb walking along the slow treadmill belt, the limb walking along the fast belt made either one (1 : 1 mode) or two steps (1 : 2); strategies could interchange. The results of the study suggest the preservation of the integration of the locomotor networks of the two limbs with a significant mismatch of their sensory inputs.



ЭКСПЕРИМЕНТАЛЬНАЯ ПАТОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ
EFFECT OF TAURINE ON MANIFESTATION OF AUDIOGENIC EPILEPSY IN RATS WITH PENDULUM MOVEMENTS
Abstract
A decrease of taurine in hippocampus of the line of rats with pendulum movements (PM), predisposed to audiogenic epilepsy, was shown. Taurine (aminoethanesulfonic acid) is known to be an anticonvulsant drug. The aim of the present work was to verify the predictive validity of taurine in rats with pendulum movements (PM). In neonatal period the exogenous taurine administration did not influence a convulsive activity at the age of 1.5 and 3 months in PM rats. The increase in the number of audiogenic seizures after taurine injections was found in adolescent period in 1.5 months and in prolonged point – in 3 months. The number of abortive seizures decreased under acute injection of taurine in adult PM rats, but the level of ictal and postictal indicators restored one month later, at the age of 4 months. Obtained results indicate the absence of effect of taurine administered to rats in the neonatal age, while at the long-term scale, the rats showed the increasing seizure activity under the action of taurine in adolescent period and confirm the predictive validity of this drug in adult PM rats.



КЛЕТОЧНАЯ НЕЙРОФИЗИОЛОГИЯ
EFFECT OF GLYCOLYSIS SUPRESSION ON ULTRASTRUCTURE OF THE HIPPOCAMPAL GIANT SYNAPSES
Abstract
Suppression of glycolysis in the rat hippocampal formations was induced by daily intracerebroventricular injection of 2-deoxy-D-glucose for 10 days. Using electron microscopy, a disturbance of morphological interactions of axonal terminals of granular neurons with perisynaptic astrocytic processes was found. At the same time, both the determinant ultrastructural characteristics of giant synapses and two types of functional contacts (asymmetric chemical active zones with dendritic spines and symmetric adhesive junctions with dendrites) were retained. However, they showed morphological signs of a weakening of synaptic processes, which were expressed in a decrease in the number of intraterminal active zones, clustering of synaptic vesicles, and their removal from neurotransmitter release sites. Compared to the norm, an increase in the number of small mitochondria with an electron-dense matrix and the evidence of initiation of glycogen synthesis in the form of glycosomes were found in the giant terminals. The data obtained indicate that the giant synapses of the hippocampal mossy fibers are a plastic, self-correcting system that is able to function by adapting its own bioenergetic metabolism, when brain glycolysis is suppressed.



ДИСКУССИОННЫЕ СТАТЬИ
PARADIGM CHANGE IN COGNITIVE SCIENCES
Abstract
Since the 1950s, the dominant paradigm in the cognitive sciences has been cognitivism, which emerged as an alternative to behaviorism, and predominantly views cognitive processes as various kinds of “computations” similar to those performed by the computer. Despite significant advances made in the last quarter of the 20th century within this paradigm, it does not satisfy many scientists because it could not adequately explain some features of cognitive processes. Connectionism, which emerged somewhat later, recognizes the role of computational processes, but as their basis considers a neural network, which is a much better model of brain functioning than Turing-type computations. Neural networks, unlike the classical computer, demonstrate robustness and flexibility in the face of real-world problems, such as increased input noise, or blocked parts of the network. They are also well suited for tasks requiring the parallel resolution of multiple conflicting constraints. Despite this, the analogy between the functioning of the human brain and artificial neural networks is still limited due to radical differences in system design and associated capabilities. Parallel to the paradigms of cognitivism and connectionism, the notions that cognition is a consequence of purely biological processes of interaction between the organism and the environment have developed. These views, which have become increasingly popular in recent years, have taken shape in various currents of the so-called enactivism. This review compares the theoretical postulates of cognitivism, connectionism, and enactivism, as well as the predictive coding paradigm and the free energy principle.



EVOLUTIONARY PATH OF CONSCIOUSNESS AND REASON: COGNITOME FROM A PHILOSOPHICAL PERSPECTIVE
Abstract
The ability of an organism to experience subjective states is an object of research for many disciplines of science. This article seeks to consider consciousness on the foundation of advances in neuroscience, cognitive science, anthropology, and philosophy. Particular attention is given to the concept of “cognitome” suggested by K.V. Anokhin. We agree with understanding conscious activity as a particular ability of an organism, which cannot be reduced to a mass of simpler systems. However, we believe that subjective ability for the cognition or “anticipatory reflection” of the environment must be considered under the history of natural evolution. We suggest that a particular interference pattern that emerges from the activity of neural domain systems can be a foundation for a critical enhancement of a system’s efficiency and cause further evolution of cognitive systems. This theory is coherent with the most elaborated neuroscientific explanations of consciousness and can explain the direct match between the neural system’s dynamics and states of subjective reality.



ИНФОРМАЦИЯ
Авторский указатель, том 72, 2022



Опечатки, замеченные в “Журнале высшей нервной деятельности им. И.П. Павлова”, том 72, № 1, 2022


