Interval inhalation application of an oxygen-helium mixture reverses the effects of cerebral arterial air embolism

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Oxygen-helium mixture demonstrates marked efficacy of helium mixtures in animal models of ischemia/reperfusion, which opens the possibility of its use as an emergency measure for therapy of vascular embolism. We modelled cerebral arterial air embolism by injecting an air bubble into the internal carotid artery of awake rats. Inhalation of a heated oxygen-helium mixture immediately after modelling arterial embolism normalizes physiological abnormalities and prevents ischemic brain damage, whereas application of a heated oxygen-helium mixture 2 hours after modelling arterial embolism significantly worsens the condition of the animals.

Толық мәтін

Рұқсат жабық

Авторлар туралы

V. Palikov

Institute of Biomedical Problems of the Russian Academy of Sciences; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Moscow; Pushchino

N. Pavlov

Institute of Biomedical Problems of the Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Moscow

A. Ismailova

Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Pushchino

R. Amirov

Institute of Biomedical Problems of the Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Moscow

I. Dyachenko

Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Pushchino

N. Borozdina

Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Pushchino

A. Bervinova

Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Pushchino

A. Logunov

Closed joint stock company «Specialized Design Bureau of Experimental Equipment at the Institute oof Medical and Biological Problems of the Russian Academy of Sciences»

Email: baranov-vm@mail.ru
Ресей, Khimki

A. Murashev

Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: baranov-vm@mail.ru
Ресей, Pushchino

V. Baranov

Institute of Biomedical Problems of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: baranov-vm@mail.ru
Ресей, Moscow

Әдебиет тізімі

  1. Министерство здравоохранения Российской федерации. Клинические рекомендации. Клинические рекомендации – Ишемический инсульт и транзиторная ишемическая атака у взрослых – 2021-2022-2023. 2021. 168 c.
  2. Archer D.P., Walker A.M., McCann S.K., Moser J.J., Appireddy R.M. Anesthetic Neuroprotection in Experimental Stroke in Rodents: A Systematic Review and Meta-analysis. Anesthesiology. 2017. 126 (4): 653–665.
  3. Fakkert R.A., Karlas N., Schober P., Weber N. C., Preckel B., van Hulst R. A., Weenink R.P. Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies. Critical Care. 2023. 27 (1): 282.
  4. Li Z., Li G., Li Y., Chen Y., Li J., Chen H. Flow field around bubbles on formation of air embolism in small vessels. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118(26):e2025406118.
  5. Pagel P.S., Krolikowski J.G., Shim Y.H., Venkatapuram S., Kersten J.R., Weihrauch D., Warltier D.C., Pratt P.F. Jr. Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. Anesth Analg. 2007. 105 (3): 562–569.
  6. Palikov V.A., Pavlov N.B., Amirov R.R., Ismailova A.M., Borozdina N.A., Palikova Y.A., Dyachenko I.A., Khokhlova O.N., Ponomareva T.I., Rykov V.A., Logunov A.T., Murashev A.N., Baranov V.M. Effect of a helium and oxygen mixture on physiological parameters of rats with cerebral arterial air embolism. Frontiers in physiology. 2024. 15: 1388331.
  7. Pan Y., Zhang H., Acharya A.B., Cruz-Flores S., Panneton W.M. The effect of heliox treatment in a rat model of focal transient cerebral ischemia. Neurosci Lett. 2011. 497 (2): 144–147.
  8. Pan Y., Zhang H., VanDeripe D.R., Cruz-Flores S., Panneton W.M. Heliox and oxygen reduce infarct volume in a rat model of focal ischemia. Exp Neurol. 2007. 205 (2): 587–90.
  9. Randhawa A.S., Pariona-Vargas F., Starkman S., Sanossian N., Liebeskind D. S., Avila G., Stratton S., Gornbein J., Sharma L., Restrepo-Jimenez L., Valdes-Sueiras M., Kim-Tenser M., Villablanca P., Conwit R., Hamilton S., Saver J.L. Beyond the Golden Hour: Treating Acute Stroke in the Platinum 30 Minutes. Stroke. 2022. 53 (8): 2426–2434.
  10. Wang Q., Zhang X., Suo Y., Chen Z., Wu M., Wen X., Lai Q., Yin X., Bao B. Normobaric hyperoxia therapy in acute ischemic stroke: A literature review. Heliyon. 2023. 10 (1): e23744.
  11. Zhong W., Cheng J., Yang X., Liu W., Li Y. Heliox Preconditioning Exerts Neuroprotective Effects on Neonatal Ischemia/Hypoxia Injury by Inhibiting Necroptosis Induced by Ca2+ Elevation. Transl Stroke Res. 2023. 14 (3): 409–424.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
2. Fig. 1. Results of functional tests before CAE modeling and 24 hours after CAE modeling. (a) – body temperature, (б) – minute respiratory volume, (в) – blood pressure, (г) – horizontal activity in the open field. Note: * – p < 0.05 in comparison with CAE group, + – p < 0.05 in comparison with parameters before CAE modelling of one group.

Жүктеу (270KB)
3. Fig. 2. Histological images of frontal brain slices, 24 hours after CAE. Hematoxylin and eosin staining. Magnification x100. (a) – ischemic stroke foci in an animal with CAE; (б) – brain of an animal with CAE and HOM therapy immediately after CAE; (в) – brain of an animal with CAE and HOM therapy one hour after CAE; (г) – hemorrhagic stroke foci in an animal with CAE and HOM therapy 2 hours after CAE.

Жүктеу (753KB)

© Russian Academy of Sciences, 2024