Melancholic Depression is Followed by the Increased Serum Nerve Growth Factor Level

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Resumo

The aim of the work was to investigate the nerve grown factor (NGF) level in the blood serum in patients with melancholic depression (MD). The investigated group consists of 23 patients. At admission in the clinic (before any antidepressive treatment) the NGF concentration in patient’s serum was 278.28 ± 43.68 pg/mL that was significantly higher in comparison with controls 239.51 ± 22.15 pg/mL, (p < 0.05), respectively. It is supposed, that the increased NGF level in serum of the MD patients can be connected with the impairment of the functioning of the brain-blood barrier and the increase of its permeability for the NGF.

Sobre autores

M. Uzbekov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

S. Shikhov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

V. Krjukov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

V. Brilliantova

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

V. Krasnov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

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Declaração de direitos autorais © М.Г. Узбеков, С.Н. Шихов, В.В. Крюков, В.В. Бриллиантова, В.Н. Краснов, 2023