Blood Content of Pro-Inflammatory Chemokines in Patients with First Episode of Schizophrenia before Therapy


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Abstract

The role of chemokines involved in the processes of neuroinflammation is not well understood in schizophrenia, especially in patients with the first episode of the disease. The aim of the study: to study the content of pro-inflammatory chemokines in the blood of patients with the first episode of paranoid schizophrenia. We examined 18 patients with a diagnosis of F20.09, the control group – 35 people. Determination of the content of 13 chemokines in blood serum was carried out by flow fluorometry. Blood sampling was carried out before the start of therapy. In patients with the first episode of schizophrenia before the appointment of therapy, an increase in the blood level of CCL4 (MIP-1β) by 1.1 times, CXCL9 (MIG) – by 1.4 times, CCL11 (Eotaxin), CXCL5 (ENA-78), CXCL10 (IP-10) – 1.5 times, CXCL1 (GRO-α) – 1.6 times, СCL20 (MIP-3α) – 2.1 times, CXCL8 (IL-8) – 21.0 times. The results obtained indicate the importance of neuroimmune inflammation in the manifestation of schizophrenia with the involvement of chemokines in this process.

About the authors

A. V. Sakharov

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

S. E. Golygina

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

A. S. Prokhorov

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

P. P. Tereshkov

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

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Copyright (c) 2023 А.В. Сахаров, С.Е. Голыгина, А.С. Прохоров, П.П. Терешков