Features оf Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease Against the Background of Course Therapy with Steroid Glycoalkaloids

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Abstract

Parkinson’s disease is a chronic neurodegenerative disease, one of the pathobiochemical manifestations of which is an imbalance of neurotransmitters in the brain. The aim of this work is to study the effect of glycoalkaloids on changes in the level of neurotransmitters and markers of brain neurodegeneration in rats with experimental Parkinson’s disease. Parkinson’s disease was modeled in animals by intracerebral administration of rotenone. The studied glycoalkaloids were administered orally at a dose of 0.06 mg / kg, a course of 28 days after pathology modeling. The study found that the use of the analyzed glycoalkaloids did not affect the concentration of dopamine and serotonin, and also significantly (p < 0.05) reduced the level of ACh by 35.9% and increased the level of GABA by 55.1%, reduced the concentration of S100β protein by 68.6% and increased the level of BDNF by 52.4%.

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About the authors

V. A. Voronov

Pyatigorsk Medical and Pharmaceutical Institute — branch of the Volgograd State Medical University of the Ministry of Health of Russia

Author for correspondence.
Email: a54545a@mail.ru
Russian Federation, Pyatigorsk

D. I. Pozdnyakov

Pyatigorsk Medical and Pharmaceutical Institute — branch of the Volgograd State Medical University of the Ministry of Health of Russia; “Pyatigorsk State Research Institute of Balneology” branch of the Federal State Budgetary Institution “Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency”

Email: a54545a@mail.ru
Russian Federation, Pyatigorsk; Pyatigorsk

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2. Fig. 1. The effect of pramipexole and glycoalkaloids on changes in the concentration of neurotransmitters in brain tissues in rats with Parkinson's disease. - reliably relative to LO; ■ — reliably relative to NC.

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3. Fig. 2. The effect of pramipexole and a mixture of solanine and chaconin on changes in the concentration of S100ß protein and BDNF substance in brain tissues in rats with Parkinson's disease. - reliably relative to LO; ■ — reliably relative to NC.

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