Comparative analysis of changes in heart rate parameters of female and fetal rats under conditions of hemic hypoxia

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We performed a comparative analysis of changes in the cardiac activity parameters under conditions of hemic hypoxia created by the introduction of sodium nitrite in female rats and their fetuses on gestation days 18 (E18) and 20 (E20). In the last trimester of prenatal development, under the conditions of the hemic hypoxia model, an increase in the sensitivity of the female organism to oxygen deficiency is observed at E20 compared to E18. Conversely, an analysis of the physiological indices of the fetuses revealed a greater resistance of the fetal cardiovascular system to hypoxia on E20 than on E18. Analysis of heart rate variability (HRV) showed the active participation of the catecholaminergic system in the emergency mobilization of energy and metabolic resources in fetuses.

Sobre autores

N. Vdovichenko

Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences

Autor responsável pela correspondência
Email: vdona@mail.ru
Rússia, St. Petersburg

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