Antioxidant activity of catecholamines during the oxidation of methyl linoleoate in Triton X-100 micelles

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The effect of catecholamines on the oxidation of methyl linoleate in Triton X-100 micelles was studied. It has been established that catecholamines do not inhibit oxidation at a pH 7.4. Inhibition is only possible in the presence of the superoxide dismutase enzyme or at lower pH levels. The reason for this effect is the interaction of anionic forms of phenols and phenoxyl radicals with oxygen with the formation of superoxide anions. High values of inhibition coefficients for catecholamines in the presence of superoxide dismutase are due to the reactions of the resulting ortho-quinones, leading to the regeneration of OH groups.

Full Text

Restricted Access

About the authors

V. A. Ryabkova

Demidov Yaroslavl State University

Email: tikhonoviv.ysu@gmail.com
Russian Federation, Yaroslavl

I. V. Tikhonov

Demidov Yaroslavl State University

Author for correspondence.
Email: tikhonoviv.ysu@gmail.com
Russian Federation, Yaroslavl

E. M. Pliss

Demidov Yaroslavl State University

Email: tikhonoviv.ysu@gmail.com
Russian Federation, Yaroslavl

References

  1. I. Tikhonov, V. Roginsky, and E. Pliss, Int. J. Chem. Kinet. 41, 92 (2008). https://doi.org/10.1002/kin.20377
  2. I. Tichonov, V. Roginsky, and E. Pliss, Eur. J. Lipid Sci. Technol. 112, 887 (2010). https://doi.org/10.1002/ejlt.200900282
  3. V. Roginsky, Arch. Biochem. Biophys. 414, 261 (2003). https://doi.org/10.1016/S0003-9861(03)00143-7
  4. V. Roginsky, and E.A. Lissi, Food Chem. 92, 235 (2005). https://doi.org/10.1016/j.foodchem.2004.08.004
  5. K. Jodko-Piorecka, and G. Litwinienko, Free Radic. Biol. Med. 83, 1 (2015). https://doi.org/10.1016/j.freeradbiomed.2015.02.006
  6. D. Loshadkin, V. Roginsky, and E. Pliss, Int. J. Chem. Kinet. 34, 162 (2002). https://doi.org/10.1002/kin.10041
  7. V. Roginsky, and T. Barsukova, Chem. Phys. Lipids 111, 87 (2001). https://doi.org/10.1016/S0009-3084(01)00148-7
  8. V. Roginsky, T. Barsukova, D. Loshadkin, and E. Pliss, Chem. Phys. Lipids 125, 49 (2003). https://doi.org/10.1016/S0009-3084(03)00068-9
  9. V. Roginsky, Free Radic. Res. 35, 55 (2001). https://doi.org/10.1080/10715760100300591
  10. I.V. Moskalenko, and I.V. Tikhonov, Russ. J. Phys. Chem. B 16, 602 (2022). https://doi.org/10.1134/S1990793122040121
  11. V.M. Costa, R. Silva, L.M. Ferreira, P.S. Branco, F. Carvalho, M.L. Bastos, R.A. Carvalho, M. Carvalho, and F. Remiao, Chem. Res. Toxicol. 20, 1183 (2007). https://doi.org/10.1021/tx7000916
  12. T.V. Sirota, Biophysics. 65, 548 (2020). https://doi.org/10.1134/S0006350920040223
  13. N.A. Mautjana, J. Estes, J.R. Eyler, and A. Brajter-Toth, Electroanalysis 20, 1959 (2008). https://doi.org/10.1002/elan.200804279
  14. I. Iftikhar, K. Abou El-Nour, and A. Brajter-Toth, Electrochim. Acta 249, 145 (2017). https://doi.org/10.1016/j.electacta.2017.07.087
  15. I.F. Rusina, T.L. Veprintsev, and R.F. Vasil’ev, Russ. J. Phys. Chem. B 16, 50 (2022). https://doi.org/10.1134/S1990793122010274
  16. F. Mack, and H. Bonisch, Naunyn-Schmiedeberg’s Arch. Pharmacol. 310, 1 (1979). https://doi.org/10.1007/BF00499868
  17. N.Yu. Gerasimov, O.V. Nevrova, I.V. Zhigacheva, I.P. Generozova, and A.N. Goloshchapov, Russ. J. Phys. Chem. B 17, 135 (2023). https://doi.org/10.1134/S1990793123010049
  18. L.N. Shishkina, M.V. Kozlov, T.V. Konstantinova, A.N. Smirnova, and V.O. Shvydkiy, Russ. J. Phys. Chem. B 17, 141 (2023). https://doi.org/10.1134/S1990793123010104
  19. K. Jodko-Piorecka, B. Sikora, M. Kluzek, P. Przybylski, and G. Litwinienko, J. Org. Chem. 87, 1791 (2022). https://doi.org/10.1021/acs.joc.1c02308

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Dependence of the rate of LH oxidation in W micelles on the concentration of epinephrine, norepinephrine, DOPA, and dopamine in the absence (dark dots) and in the presence of 100 units/ml of SOD (light dots) at pH = 7.4.

Download (53KB)
Indexing metadata
3. 2. Kinetic curves of oxygen absorption during LH oxidation in micelles without an inhibitor (1) and in the presence of 4 · 10-6 mol·l–1 DOPA (2), dopamine (3) and norepinephrine (4); [SOD] = 100 units/ml, pH = 7.4.

Download (46KB)
Indexing metadata
4. Scheme

Download (20KB)
Indexing metadata
5. 3. Dependence of the rate of LH oxidation in micelles on the concentration of dopamine at pH = 4.0 (1), 5.0 (2), 6.0 (3), 7.4 (4).

Download (47KB)
Indexing metadata

Copyright (c) 2024 Russian Academy of Sciences