SEX AND STRAIN DIFFERENCES BETWEEN DISC1-L100P AND C57BL/6 MICE IN PASSIVE AVOIDANCE CONDITIONING DEFINATION
- Authors: Chizhova N.D.1,2, Smirnova K.V.1,3, Dubrovina N.I.1, Lipina T.V.1, Amstislavskaya T.G.1,3
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Affiliations:
- Scientific Research Institute of Neurosciences and Medicine
- Institute of Cytology and Genetics
- Novosibirsk State University
- Issue: Vol 73, No 3 (2023)
- Pages: 425-432
- Section: ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬ
- URL: https://cardiosomatics.orscience.ru/0044-4677/article/view/652039
- DOI: https://doi.org/10.31857/S004446772303005X
- EDN: https://elibrary.ru/TTCZGH
- ID: 652039
Cite item
Abstract
Sex and strain differences in the passive avoidance learning and extinction in male and female of DISC1-L100P mice and wild-type control mice were investigated. It was shown that male and female mice of both strains were well trained in the conditioned response of passive avoidance, but differed in fear memory extinction, the ability to form a new memory trace about the safety of the previously punished dark compartment of apparatus in the procedure of repeated testing. There was a deficit of fear memory extinction in females of DISC1-L100P and C57BL/6 mice compared to males. At the same time, interstrain differences in the dynamics of passive avoidance extinction in female mice of these strains were revealed. Results also showed that DISC1-L100P males differed from C57BL/6 in terms of the time to achieve complete extinction of this reaction.
Keywords
About the authors
N. D. Chizhova
Scientific Research Institute of Neurosciences and Medicine; Institute of Cytology and Genetics
Author for correspondence.
Email: chizhovand@neuronm.ru
Russia, Novosibirsk; Russia, Novosibirsk
K. V. Smirnova
Scientific Research Institute of Neurosciences and Medicine; Novosibirsk State University
Email: amstislavskayatg@neuronm.ru
Russia, Novosibirsk; Russia, Novosibirsk
N. I. Dubrovina
Scientific Research Institute of Neurosciences and Medicine
Email: amstislavskayatg@neuronm.ru
Russia, Novosibirsk
T. V. Lipina
Scientific Research Institute of Neurosciences and Medicine
Email: amstislavskayatg@neuronm.ru
Russia, Novosibirsk
T. G. Amstislavskaya
Scientific Research Institute of Neurosciences and Medicine; Novosibirsk State University
Author for correspondence.
Email: amstislavskayatg@neuronm.ru
Russia, Novosibirsk; Russia, Novosibirsk
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