NEUROIMAGING (RESTING-STATE fMRI) AND NEUROPSYCHOLOGICAL CHARACTERISTICS OF NON-CONVERTERS WITH CLINICAL HIGH RISK FOR PSYCHOSIS

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Abstract

Based on the concept of clinical high risk for psychosis, we aimed to reveal characteristics of brain functioning (resting-state fMRI) and neurocognition in 27 patients with non-psychotic mental disorders with attenuated schizophrenia symptoms who did not transit to psychosis for a long period of observation, in contrast to 24 patients with first-episode schizophrenia and 27 mentally healthy subjects. The main group was characterized by higher local coherence of BOLD signal in the right visual cortex and higher functional connectivity between the occipital component of the visual network and the right prefrontal component of the salience network (as compared to patients with schizophrenia). In both patient groups, a decreased productivity in verbal fluency tests was found. The neuroimaging and neuropsychological findings in the main group can be considered via the dichotomy of protective and pathological mechanisms in patients with high risk for psychosis.

About the authors

I. S. Lebedeva

Mental Health Research Center

Author for correspondence.
Email: lebedeva-i@yandex.ru
Russia, Moscow

Y. R. Panikratova

Mental Health Research Center

Email: lebedeva-i@yandex.ru
Russia, Moscow

E. G. Abdullina

Mental Health Research Center

Email: lebedeva-i@yandex.ru
Russia, Moscow

V. V. Migalina

Mental Health Research Center

Email: lebedeva-i@yandex.ru
Russia, Moscow

D. V. Tikhonov

Mental Health Research Center

Email: lebedeva-i@yandex.ru
Russia, Moscow

M. A. Omelchenko

Mental Health Research Center

Email: lebedeva-i@yandex.ru
Russia, Moscow

V. G. Kaleda

Mental Health Research Center

Email: lebedeva-i@yandex.ru
Russia, Moscow

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Copyright (c) 2023 И.С. Лебедева, Я.Р. Паникратова, Е.Г. Абдуллина, В.В. Мигалина, Д.В. Тихонов, М.А. Омельченко, В.Г. Каледа