Vol 13, No 1 (2022)

Original articles

The structural-geometric and functional parameters of the heart in patients after mitral prosthetics with new full-flow valves in the long-term period

Perekopskaya V.S., Morova N.A., Tsekhanovich V.N.


Aim. To compare the results of mitral valve replacement with the full-flow mechanical valve «MedInzh-ST» and the classical prosthesis «MedInzh-2», to learn the structural and functional parameters of the heart depending from the prosthesis in the long-tern period.

Material and methods. From 2015 to February 2020 years an the basis of the cardio-surgical department of the «Regional clinical Hospital» 116 patients, in order to correct defects, were underwent mitral prosthetics with «MedInzh» valves. Of these 55 patients received a new full-flow valve «MedInzh-ST». 61 patients – a classical «MedInzh-2». Before surgery and in the long-term period all patients were underwent transthoracic echocardiography with using expert-class devices. In the long-tern postoperative period 34 patients were underwent echocardiographic research after implantation full-flow valves and 40 patients after prosthetics of classical prosthesis.

Results. The choice of the prosthesis model did not affect the incidence of postoperative complications and the rate of hospital mortality. In all cause of death is not associated with impaired function of the prosthesis. All patients before the discharge from hospital were fixed the positive effect from surgical treatment. In the long-term postoperative period between patients after implantation of full-flow valves, the cases of prosthetic platelets were not registered. One patient was diagnosed with prosthetic thrombosis after implantation of a classical prosthesis, which required further reprosthetics. There were no signs of prosthetic endocarditis and paraprosthetic fistula in both groups. There were no significant differences in the structural and geometric parameters of the heart in all patients.

Conclusion. Analysis of the functional characteristics of the new full-flow valve «MedInzh-ST» in the long-term period allows us to conclude that the new valve model meets modern requirements for efficiency and safety.

CardioSomatics. 2022;13(1):4-10
pages 4-10 views

Predictive role of MTHFR, FGB, F2 and F5 genes polymorphisms in the development of pulmonary embolism

Kriuchkova N.M., Chernova A.A., Nikulina S.Y., Maksimov V.N., Gurazheva A.A.


Aim. Research the relationship of gene polymorphisms (MTHFR, FGB, F2, F5) with the development of pulmonary embolism (PE).

Material and methods. The study involved 120 people (main group) who underwent PE. Mean age is 63.22±3.16 years (66 men, mean age 60.24±3.17 years; 54 women, mean age 66.19±3.67 years). The control group was composed of Research Institute of Internal and Preventive medicine (Novosibirsk) DNA bank (comparable to the main group by gender and age). This DNA bank was formed during a series of population-based screening. The material for the study includes whole blood, plasma and serum samples, DNA samples, as well as medical records of patients undergoing PE. DNA extraction from venous blood was performed by the phenol-chloroform method. FGA (Del/Ins) rs35496957 was genotyped using polymerase chain reaction (PCR) with flanking primers-8202 A/G, rs11697325 mmp9 – using PCR with RFLP. Polymorphisms of genes MTHFR, FGB, F2, F5 were tested by real-time PCR on test systems produced by DNA-technology (Russia) on a DTPrime device (Russia). For structuring and statistical data processing Microsoft Excel and the Microsoft Office software package and the STATISTICA (USA) software package for statistical analysis were used. The study includes the calculation of the following output data and parameters based on the collected incoming statistical data: standard deviation, calculating the mean square value, Pearson's chi-square, likelihood ratios, Fisher's exact test and linear-by-linear association.

Results. It was found that the odds ratio of developing PE in men carriers of the TT genotype of the C677T polymorphism of the MTHFR gene at the age of 65 years and older was 4.43 times higher than in carriers of the other two genotypes (95% confidence interval 1.33–14.73; p=0.019). There was a tendency of more frequent detection of the genotype GG polymorphism rs1800790 (-455 G>A) of the FGB gene among men individuals of the main group compared with the control group (63.6 and 54.0%, respectively). There was also a decrease in the number of respondents with the AA genotype of the rs1800790 polymorphism (-455 G>A) of the FGB gene in the group of both genders. There was a tendency of more frequent PE cases among women individuals with genotype GG and GA of the rs1799963 polymorphism of the F2 gene in the main group (85.20 and 14.80%, respectively).

Conclusion. Further research of genetic factors’ role in the occurrence of PE is extremely important for clinical practice taking into consideration the possibility of developing a personalized approach to treatment and prevention of the diseases related to disorders in the hemostatic system.

CardioSomatics. 2022;13(1):12-16
pages 12-16 views

Case reports

Cardiovascular diseases induced by radiotherapy. Case report

Barsukov A.V., Borisova E.V., Glukhovskoi D.V., Glebova S.A., Rud S.D., Akhmetshin I.M., Sveklina T.S., Chumak B.A.


The article presents the current understanding of the problem of radiation therapy (RT)-induced heart diseases. The paper is based on a clinical case of restrictive cardiomyopathy in a female previously cured of Hodgkin's lymphoma with RT. The importance of using modern imaging technologies aimed at verifying pathomorphological changes in the myocardium that cause the development of heart failure with preserved left ventricular ejection fraction is reflected. The given clinical case shows the combination of visceral complications arising in the long term after RT in oncohematological patients.

CardioSomatics. 2022;13(1):17-22
pages 17-22 views


Digital wearable devices in cardiac rehabilitation: patient need and satisfaction. Literature Review

Lyamina N.P., Kharytonov S.V.


Currently there is a rapid progress in the new technologies development that expand the possibilities of home cardiac rehabilitation and telerehabilitation. It seems relevant to use wearable devices to monitor hemodynamic parameters, electrical activity of the heart, physical activity of patients in cardiac rehabilitation. This is especially important when monitoring the condition of elderly people and patients with comorbid conditions. The perspectives of sensors integration for assessment of not only hemodynamic parameters, but also the assessment of sensors that allow to monitor some metabolic indicators, human behavior are extremely important for cardiac patients. The use of digital technologies will significantly speed up the process of integrating cardiac rehabilitation into the general health care system. This will also allow to assess the need of high-quality medical care for the maximum of patients to whom it is indicated.

CardioSomatics. 2022;13(1):23-30
pages 23-30 views

Optimizing therapy for cardiovascular diseases: proven organ-protective and preventive effects of pitavastatin and lercanidipine: A review

Bubnova M.G.


The article aims to systematize the available data on the current use of statins and calcium channel antagonists (CA) for cardiovascular disorders therapy and to analyze the results of clinical trials focused on pitavastatin and lercanidipine. The article addresses the safety and tolerability of statins and CA and their use in the treatment of various conditions. Pharmacological features, preventive and organ-protective effects of pitavastatin and lercanidipine are described. The publications from the MEDLINE/PubMed, Scopus, Cochrane Library, eLIBRARY, and Google Scholar databases over the past 25 years were analyzed. The evidence presented in the article warrants the more extensive use of statins and CA in the treatment of patients with cardiovascular disease.

CardioSomatics. 2022;13(1):31-42
pages 31-42 views

The mitral insufficiency in connective tissue dysplasia. What should a doctor know today? A review

Martyanova Y.B., Chernysheva E.N., Kondratiev D.A., Dzemeshkevich S.L., Tarasov D.G., Ljaljukova E.A.


The problem of the mitral valve (MV) dysfunction, both in isolation and combination forms with other anomalies and lesions of connective tissue structures, is very current. Mitral insufficiency (MI) in case of the connective tissue dysplasia is the most common valvular pathology, accompanied by different degrees of severity. Nowadays the progradient development of functional and clinical symptoms of this disease has been studied, the questions of epidemiology, diagnosis and prognosis have been clarified and reconsidered. There are important issues of correct diagnosis, time and method of treatment, the decision of usage a valve-repair or valve prosthesis in the certain clinical situation. All these practical algorithm steps depend on the clinical and surgical experience of the medical institutions which work with this pathology. The purpose of this article is to expand the knowledge of practical doctors in the issue of MI in case of connective tissue dysplasia, including the questions from the model of the MV structure to modern methods of treatment which are described in the contemporary literature.

CardioSomatics. 2022;13(1):44-50
pages 44-50 views

Current guidelines for β-adrenoblockers use in cardiovascular diseases: focus on metoprolol succinate CR/XL: A review

Bubnova M.G.


The objective of this review was to systematize current data on the β-adrenoblockers (β-ABs) used in the treatment of cardiovascular diseases and to analyze the results of studies performed with a focus on metoprolol succinate controlled release/extended release (CR/XL) formulation. The article addresses issues related to pharmacological features of metoprolol succinate CR/XL, the use of β-AB in arterial hypertension, coronary heart disease, chronic heart failure, and cardiac arrhythmias based on international and Russian clinical guidelines. Results of randomized clinical trials evaluating the efficacy of metoprolol succinate CR/XL are presented. In preparing the literature review, a review of publications over the past 34 years in the MEDLINE/PubMed, Scopus, Cochrane Library, eLIBRARY, and Google Scholar databases was performed. The presented data indicate the need for more extensive use of β-ABs, including metoprolol succinate CR/XL, in clinical practice.

CardioSomatics. 2022;13(1):51-62
pages 51-62 views

Adrenomedullin is a biological marker of heart failure: review of modern literature Amina M. Alieva*1, Natalia

Alieva A.M., Teplova N.V., Voronkova K.V., Pinchuk T.V., Valiev R.K., Shnakhova L.M., Rahaev A.M., Nikitin I.G.


It has been proven that in patients with heart failure (HF), there is an increased level of adrenomedullin (ADM) in plasma. Biomarker indices correlate with the severity of hemodynamic dysfunction, as well as with neurohumoral indices, which are activated depending on the severity of congestive circulatory failure. In addition, the expression of the ADM gene in the heart and kidneys is increased in experimental and clinical HF. A small number of studies have examined the effect of ADM infusion. These studies have generally shown that hormone infusion has beneficial hemodynamic effects and promotes the maintenance/improvement of renal function, but most of the studies have been short-lived. The available results suggest that increasing ADM levels reduce the negative effects of vasoconstriction and sodium retention. A better understanding of the role of a biological marker in congestive circulatory failure may lead to the development of drugs that target ADM receptors.

CardioSomatics. 2022;13(1):64-69
pages 64-69 views

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