CardioSomaticsCardioSomatics2221-71852658-5707Eco-Vector4508510.26442/CS45085Research ArticleThe functional significance of vasomotor arteries dysfunction in the clinical assessment of myocardial ischemia in case of carbohydrate metabolism disorderTatarchenkoI. P-PozdnyakovaN. Vpozdnyakova-n-v@rambler.ruMordovinaA. G-MorozovaO. I-Penza Extension Course Institute for Medical PractitionersFederal State Health Institution, Medical Unit−59, Penza1506201452313524092020Copyright © 2014, Eco-Vector2014We investigated the relationship between the severity of silent myocardial ischemia and the functional state of arteries endothelium. We studied the significance of violations of vasomotor function with the loss of the ability to flow-dependent vasodilation as a risk factor, which increases the probability of the episodes of silent myocardial ischemia among patients with Type II DM. We observed 128 patients (66 male and 62 female), average age was 59,3±4,7. Each patient signed an agreement to take part in our research as a volunteer. The agreement was adopted by the local ethics committee.Patients with coronary heart disease and Type II DM had dominating daily duration of episodes of myocardial ischemia and a maximum depth of ST segment depression. Besides, they had reduced endothelium-dependent vasodilation reaction (EDVD=3,7±1,1%). The violation of the functional state of the vascular endothelium correlates with the registration frequency (R=-0,68; p <0,05) and the duration of episodes of silent myocardial ischemia (R=-0,53; p <0,01).silent myocardial ischemiavasomotor function of arteriesType II Diabetes Mellitusбезболевая ишемия миокардавазомоторная функция артерийсахарный диабет типа 2[Zarich S.W, Nesto R.W. Diabetic cardiomyopathy. Am Heart J 1989; 118 (5): 1000-12.][Killip T. Silent Myocardial Ischemia: Some good news. Circulation 1997; 95: 1992-3.][Schoenenberger A.W, Jamshidi P, Kobza R et al. Progression of coronary artery disease during long - term follow - up of the Swiss Interventional Study on Silent Ischemia Type II (SWISSI II). Clin Cardiol 2010; 33 (5): 289-95.][Jermendy G, Davidovits Z, Khoor S. Silent coronary artery disease in diabetic patients with cardiac autonomic neuropathy. Diabetes Care 1994; 17: 1231-2.][Gokcel A, Aydin M, Yalcin F. Silent coronary artery disease in patients with type 2 diabetes mellitus. Acta Diabetol 2003; 40: 176-80.][Dzau V, Bernstein K, Celermajer D et al. Pathophysiologic and therapeutic implications of tissue ACE: a consensus report. Cardiovasc Drugs Ther 2002; 16 (2): 149-60.][Cipolla M. Diabetes and Endothelial Dysfunction: A Clinical Perspective. Endocr Rev 2001; 22 (1): 36-52.][Vanhoutte P.M, Boulanger C.M. Endotheliumdependent responses in hypertension. Hypertens Res 1995; 18 (2): 87-98.][Schachinger V, Britten M.B, Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long - term outcome of coronary heart disease. Circulation 2000; 101: 1899-906.][Celermajer D.S, Sorensen K.E. Non - invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5.]