CardioSomaticsCardioSomatics2221-71852658-5707Eco-Vector4503810.26442/CS45038Research ArticleAssessing the impact of antihypertensive therapy on ambulatory blood pressure monitoring in patients with isolated systolic hypertensionAydarovaV. A-AstahovaZ. T-KanukovaF. Ufariza.kanukova@yandex.ruBesaevaM. M-North Ossetian State Medical Academy, Vladikavkaz15032014515924092020Copyright © 2014, Eco-Vector2014The study examined the effectiveness of drug correction of high numbers of blood pressure (BP) by means of modern groups of antihypertensive drugs, the effect of a fixed combination of perindopril and indapamide on circadian blood pressure monitoring, and a commitment to patients of antihypertensive therapy, based on the opened simple randomization three groupswere formed: 1st comprised of 21 patients with isolated systolic hypertension (ISAH) and 22 patients with systolic-diastolic hypertension (SDAH) - they all received monotherapy with calcium antagonists (amlodipine 10 mg/day); Group 2 - of 16 ISAH patients and 24 SDAH patients - who received monotherapy with perindopril (2 mg/day) and the third group - of 17 patients with ISAH and 14 patients with SDAH - who received combination therapy with the drug noliprel (Servier) with a fixed combination of perindopril (2 mg) and indapamide of 0,625 mg. Treatment efficacy was assessed primarily to reduce the absolute numbers of blood pressure, and taken into account as a reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP), uncontrolled drop of which, according to the literature, in elderly patients can have fatal consequencesisolated systolic hypertensionantihypertensive therapyblood pressure monitoringизолированная систолическая артериальная гипертензияантигипертензивная терапиясуточное мониторирование АД[Кобалава Ж.Д., Котовская Ю.В. Особенности артериальной гипертонии в пожилом возрасте. Cons. Med. 2006; 6 (12): 565-70.][Остроумова О.Д., Мамаев В.И., Абакумов Ю.Е. Изолированная систолическая артериальная гипертензия. Cons. Med. 2003; 5 (5): 2-5.][Чазова И.Е., Ратова Л.Г. Современные клинические рекомендации по артериальной гипертонии. Сердце. 2008; 3: 5-11.][Шальнова С.А. Эпидемиология артериальной гипертензии в России: портрет больного. Артериальная гипертензия. 2008; 2: 5-7.][Gradman A.H. Role of angiotensin II type 1 receptor antagonists in the treatment of hypertension in patients aged or 65 years. Drugs Aging 2009; 26 (9): 751-67.][Кисляк О.А. Ингибитор АПФ лизиноприл в лечении пациентов с изолированной систолической и систоло - диастолической артериальной гипертензией. Лечебное дело. 2007; 2: 1-7.][Thijs L, Den Hond E, Nawrot T et al. Prevalence, pathophysiology and treatment of isolated systolic hypertension in the elderly. Expert Rev Cardiovasc Ther 2004; 2: 761-95.][Uzunian T.G, Boroian R.G, Zelvian P.A. Antihypertensive treatment of elderly patients with isolated systolic hypertension. Kardiologiia 2008; 48 (12): 59-64.]