CardioSomaticsCardioSomatics2221-71852658-5707Eco-Vector11091510.17816/CS110915Review ArticleThe role of rs3025058 polymorphism in the development of ischemic stroke in patients with cardiovascular diseases (review)NikulinDmitry A.<p>Cand. Sci. (Med.), Prof.</p>nevrokgma@mail.ruhttps://orcid.org/0000-0003-1591-035XChernovaAnna A.<p>D. Sci. (Med.), Prof.</p>anechkachernova@yandex.ruhttps://orcid.org/0000-0003-2977-1792NikulinaSvetlana J.<p>D. Sci. (Med.), Prof.</p>nicoulina@mail.ruhttps://orcid.org/0000-0002-6968-7627MaksimovVladimir N.<p>D. Sci. (Med.), Prof.</p>medik11@mail.ruhttps://orcid.org/0000-0002-3157-7019Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityFederal Siberian Research Clinical Center under FMBA of RussiaInstitution of Internal and Preventive Medicine091020221321241271409202216092022Copyright © 2022, Eco-Vector2022<p>Acute cerebrovascular accident (ACC) is a formidable complication of a number of cardiovascular diseases, in a significant percentage of cases leading to disability and mortality. The literature available to us provides information on the role of type 3 matrix metalloproteinase gene (MMP-3) polymorphism in the development of stroke. It is believed that MMP-3 plays an important role in the natural processes of tissue remodeling and pathological processes. The mechanism of regulation of tissue remodeling MMP-3 is based on the activation of procollagenase-1. The associations of the single-nucleotide variant rs3025058 (5A/6A) with the development of ONMK in patients with cardiovascular pathology and risk factors of its development for the implementation of measures of primary prevention of this disease are considered. The article discusses issues related to the role and identification of associations of the single nucleotide variant rs3025058 (5А/6А) with the development of stroke in patients with cardiovascular pathology. When preparing the review, publications were searched in the MEDLINE/PubMed, Scopus, Cochrane Library, PEDro, eLIBRARY databases and Google Scholar. In preparing the literature review, the analysis of publications for the last 15 years is carried out. Represented evidence suggests the need for further study and effective use of the results of the study of the rs3025058 MMP-3 polymorphism for the implementation of primary prevention measures in the development of acute cerebrovascular accident, especially in the families of these patients.</p>acute cerebrovascular accidentischemic strokearterial hypertensiondyslipidemiaatherosclerosishemostasisrs3025058острое нарушение мозгового кровообращенияишемический инсультартериальная гипертензиядислипидемияатеросклерозгемостазrs3025058[Abilleira S, Bevan S, Markus HS. The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis. J Med Genet. 2006;43(12):897–901. DOI:10.1136/jmg.2006.040808][Koch W, de Waha A, Hoppmann P, et al. Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: case-control study and a meta-analysis. Atherosclerosis. 2010;208(1):171–176. 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