Assessment of the effect of -blockers on the functional state in patients with ventricular arrhythmias: results of a comparative study

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Abstract


Aim. Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with ventricular arrhythmias (VA).

Material and methods. 120 patients with VA against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: echocardiography, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram.

Results. With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol increased exercise tolerance to a greater extent, in comparison with bisoprolol and sotalol. Nebivolol and sotalol improved the quality of life, in comparison with bisoprolol.

Conclusion. In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.


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About the authors

Iosif Z. Shubitidze

Regional Clinical Hospital №2

Author for correspondence.
Email: iosif.shubitidze@mail.ru
ORCID iD: 0000-0002-4588-9515

Russian Federation, Krasnodar

cardiologist, Regional Clinical Hospital №2

Vitalii G. Tregubov

Kuban State Medical University

Email: iosif.shubitidze@mail.ru
ORCID iD: 0000-0003-0635-3598

Russian Federation, Krasnodar

D. Sci. (Med.), Kuban State Medical University

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