The role of single-nucleotide polymorphism rs10824026 of the SYNPO2L gene in the development of atrial fibrillation in a study in the East-Siberian population

Abstract


Background. Atrial fibrillation (AF) is the most common type of heart rhythm disturbance, leading to the development of lifethreatening conditions, such as cardio embolism, heart failure, and even sudden cardiac death. In recent years, the genetic aspects of AF have been actively discussed. The largest number of genetic predictors of AF was identified after a full genome-wide association studies (GWAS). Given that so far no studies of the association of rs10824026 polymorphism of chromosome 10q22 with the development of AF have been conducted in the Russian population, we conducted this clinical study. Aim. Checking the associations of the development of AF with the single-nucleotide polymorphism rs10824026 of the SYNPO2L gene in the East-Siberian population. Materials and methods. The study design was formed in accordance with the National Standard of the Russian Federation Good Clinical Practice, GOST P 52379-2005. The study uses design - “case-control”. The main group of patients - patients with known cardiac arrhythmias by the type of AF (n=106, average age 57.0±9 years, men 49.4%, women 50.6%), the group was formed using the criteria of the World Health Organization and the European Society of cardiologists. The control group (n=105, average age 57.0±9 years, men - 50.0%, women - 50.0%) was selected by age and gender from the DNA bank of international studies MONICA (Multinational MONItoring of trends and determinants in cardiovascular disease) under a joint agreement with the Research Institute of Therapy and preventive medicine - Novosibirsk. DNA was isolated by phenol-chloroform extraction. Among other things, among the research methods, routine laboratory methods were used; instrumental data; and invasive tactics such as CAG. Results. As a result of clinical genetic testing, it was found that the frequency of G/G polymorphism of the SYNPO2L gene in patients with AF shows a statistically significant difference.

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About the authors

Kseniia Yu. Shishkova

Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: tadtaeva93@mail.ru
Krasnoyarsk, Russia
Graduate Student

Svetlana Yu. Nikulina

Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Krasnoyarsk, Russia
D. Sci. (Med.), Prof.

Vladimir A. Shulman

Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Krasnoyarsk, Russia
D. Sci. (Med.), Prof

Anna A. Chernova

Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: anechkachernova@yandex.ru
Krasnoyarsk, Russia
D. Sci. (Med.)

Vladimir N. Maksimov

Research Institute of Therapy and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Email: medik11@mail.ru
Novosibirsk, Russia
D. Sci. (Med.), Prof., Research Institute of Therapy and Preventive Medicine - Branch of the Institute of Cytology and Genetics

Anna A. Gurazheva

Research Institute of Therapy and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Email: annapalna1@mail.ru
Novosibirsk, Russia
Research Assistant, Scientific Research Institute of Therapy and Preventive Medicine - branch

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