Allelic variants of rs1800801 polymorphism in patients with stroke

Abstract


Aim. To study the association of single nucleotide polymorphism (SNP) rs556621 (G>T) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors. Material and methods. The study involved 260 patients with stroke (157 men and 103 women) and 272 patients of the control group (170 men and 102 women). The following cardiovascular pathology and risk factors were present in the patients of the main group: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. All patients underwent clinical, instrumental and molecular genetic examination. Statistical processing of the material was carried out using the set of application programs Statistica for Windows 7.0, Excel and SPSS 22. Results. As a result of the study, no statistically significant associations of genotypes and alleles of the rs1800801 polymorphism (C>T) with stroke were found in any of the analyzed groups and subgroups. Conclusion. SNP rs1800801 (C>T) does not have a significant effect on the development of stroke in people of the East Siberian population, regardless of the preceding cardiovascular pathology and risk factors.

Full Text

Restricted Access

About the authors

Svetlana Yu. Nikulina

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: nicoulina@mail.ru

D. Sci. (Med.), Prof.

Vladimir A. Shulman

Voyno-Yasenetsky Krasnoyarsk State Medical University


D. Sci. (Med.)

Anna A. Chernova

Voyno-Yasenetsky Krasnoyarsk State Medical University; Berzon Krasnoyarsk Interdistrict Clinical Hospital №20


D. Sci. (Med.)

Semen V. Prokopenko

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: s.v.proc.58@mail.ru

D. Sci. (Med.), Prof.

Dmitrii A. Nikulin

Voyno-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Scientific and Clinical Center

Email: nevrokgma@mail.ru; O

Cand. Sci. (Med.)

Irirna M. Platunova

Berzon Krasnoyarsk Interdistrict Clinical Hospital №20

Email: gkb20@mail.ru

Cand. Sci. (Med.)

Svetlana S. Tretyakova

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: tretyakova-svet@mail.ru

Cand. Sci. (Med.)

Aleksei A. Semenchukov

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: semlex@yandex.ru

Research Officer, V

Olga V. Marilovtseva

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: olguha83@mail.ru

Cand. Sci. (Med.)

Vladimir N. Chernov

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: chernovortstom@mail.ru

Cand. Sci. (Med.)

Vladimir N. Maksimov

Scientific Research Institute of Therapy and Preventive Medicine - branch of Federal Research Center Institute of Cytology and Genetics

Email: medik11@mail.ru

D. Sci. (Med.), Prof

Anna A. Gurazheva

Scientific Research Institute of Therapy and Preventive Medicine - branch of Federal Research Center Institute of Cytology and Genetics

Email: annapalna1@mail.ru

Research Assistant

References

  1. Gheorghe S.R, Craciun A.M. Matrix Gla protein in tumoral pathology. Clujul Med 2016; 89 (3): 319-21. doi: 10.15386/cjmed-579/
  2. Crosier M.D, Booth S.L, Peter I et al. Matrix Gla protein polymorphisms are associated with coronary artery calcification in men. J Nutr Sci Vitaminol (Tokyo) 2009; 55 (1): 59-65.
  3. Yoshikawa K, Abe H, Tominaga T et al. Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients. Clin Exp Nephrol 2013; 17 (6): 882-9. doi: 10.1007/s10157-013-0785-9
  4. Najafi M, Roustazadeh A, Amirfarhangi A, Kazemi B. Matrix Gla protein (MGP) promoter polymorphic variants and its serum level in stenosis of coronary artery. Mol Biol Rep 2014; 41 (3): 1779-86. doi: 10.1007/s11033-014-3027-7
  5. Del Río-Espínola A, Fernández-Cadenas I, Rubiera M et al. CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke. Pharmacogenomics 2010; 11 (6): 763-72. doi: 10.2217/pgs.10.44
  6. Harbuzova V.Iu, Matlaĭ O.I, Ataman Iu.O et al. The polymorphism of matrix Glaprotein gene in ischemic atherothrombotic stroke patients. Fiziol Zh 2012; 58 (5): 14-21.
  7. Боровиков В.П. STATISTICA: искусство анализа данных на компьютере. СПб.: Питер, 2001.
  8. Петри А., Сэбин К. Наглядная медицинская статистика: учебное пособие. Пер. с англ.; под ред. В.П. Леонова; 3-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2015.
  9. Peasey A, Bobak M, Kubinova R et al. Determinants of cardiovascular disease and other non-communicable diseases in Central and Eastern Europe: rationale and design of the HAPIEE study. BMC Public Health 2006; 6: 255.

Statistics

Views

Abstract - 6

PDF (Russian) - 0

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies