Comparative pharmacoepidemiological assessment of antianginal, antiplatelet and lipid-lowering drugs in patients with stable angina in outpatient practice in Kursk and Chisinau

Abstract


Aim. To study structure of medical purposes of anti-anginal, antiplatelet and hypolipidemic means at coronary heart disease patients in ambulatory practice of Kursk (Russian Federation) and Chisinau (Republic of Moldova). Materials and methods. During the period from October, 2017 to January, 2018 as a one-stage descriptive research, questioning of doctors of the medical organizations of Kursk and Chisinau was carried out. Questionnaires included questions on pharmacoepidemiological aspects of purpose of antianginal, antiplatelet and hypolipidemic means. Total number of respondents was 132, of them 66 (2 cardiologists and 64 therapists) - in Kursk and 66 (10 cardiologists and 56 therapists) - in Chisinau. Results. Doctors of Kursk and Chisinau have no statistically significant differences in structure of appointments of the main groups of anti-anginal means, antiplatelet and hypolipidemic drugs. The tendency to more frequent use of blockers of calcium channels and nitrovazodilatator among doctors of Chisinau while in structure of appointments of doctors of Kursk some prevalence of a trimetazidin, antiagregants and statines was noted was noted (p>0.05). Leaders in group of beta blockers were bisoprolol and metoprolol in the conditions of the pharmaceutical market of Kursk and Chisinau. Priority of the choice of blockers of calcium channels authentically differed in the considered regions only on a felodipin - in Kursk appointed it to a thicket (p<0.01). The structure of the choice of various representatives of nitrovazodilatator practically was parity in the explored regions. The leading drug from group of antiagregant the Kursk and Chisinau doctors had acetylsalicylic acid (58.1 and 76.3% respectively) while differences in use of a klopidogrel were more essential (41.9 and 23.7% respectively, p<0.05). Hypolipidemic means were provided by statines. The leading drugs from this group were rosuvastatin, atorvastatin and simvastatin. The share of purposes of two last medicines authentically differed. So in Kursk was more demanded (p<0.05), and in Chisinau - simvastatin (p<0.01). Conclusion. Priority classes in structure of assignment anti-anginal agents according to questioning of doctors of Kursk and Chisinau were b-blockers, blockers of calcic channels. Frequency of use of antiagregants and statins was comparable in the compared regions. The main share of medical assignments in the conditions of Kursk and Chisinau considered as in the relation the anti-anginal agents, and antiagregants, statins corresponds to the existing recommendations about pharmacotherapy of patients with stable angina pectoris.

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About the authors

Sergey V. Povetkin

State Medical University

Email: clinfarm@kursknet
Kursk, Russia
D. Sci. (Med.), Prof.

Oxana V. Levashova

State Medical University

Kursk, Russia
Cand. Sci. (Med.)

Elena G. Klyueva

State Medical University

Kursk, Russia
Cand. Sci. (Med.)

Victor I. Ghicavii

Nicolae Testemitanu State University of Medicine and Pharmacy

Chisinau, Republic of Moldova
D. Sci. (Med.), Prof.

Nicolae G. Batchinschi

Nicolae Testemitanu State University of Medicine and Pharmacy

Chisinau, Republic of Moldova
D. Sci. (Med.), Prof.

Lilia A. Pjdgurschi

Nicolae Testemitanu State University of Medicine and Pharmacy

Chisinau, Republic of Moldova
Cand. Sci. (Med.)

Lucia M. Turcan

Nicolae Testemitanu State University of Medicine and Pharmacy

Chisinau, Republic of Moldova
Cand. Sci. (Med.)

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