Estimated Gene Expression of SNARE Proteins in Hyppocampus of Rats after Modelled Spaceflight

A. A. Perevezentsev; Перевезенцев А. А.; K. B. Lebedeva-Georgievskaya; Лебедева-Георгиевская К. Б.; O. S. Kuznetsova; Кузнецова О. С.; A. S. Shtemberg; Штемберг А. С.

doi:10.31857/S1027813323020103

Estimated Gene Expression of SNARE Proteins in Hyppocampus of Rats after Modelled Spaceflight

作者: Perevezentsev A.A.¹, Lebedeva-Georgievskaya K.B.¹, Kuznetsova O.S.¹, Shtemberg A.S.¹
隶属关系:
1. Institute of BioMedical Problems of Russian Academy of Sciences
期: 卷 40, 编号 2 (2023)
页面: 186-192
栏目: Experimental Articles
URL: https://cardiosomatics.orscience.ru/1027-8133/article/view/653950
DOI: https://doi.org/10.31857/S1027813323020103
EDN: https://elibrary.ru/UCRDZM
ID: 653950

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详细

Our recent researches demonstrate shifts in brain activity of rats, both at behavioral and biochemical levels, induced by one of modeled impacts of interplanetary spaceflight, i.e. space radiation. Thus emerges a question, whether such shifts occur in molecular underlying processes of brain function. We have investigated the gene expression for proteins of SNARE (soluble NSF attachment receptor), responsible for fusion of transport vesicles with terminal membranes. Our result is an evidence of changes in some SNARE elements after irradiation and an indirect evidence of a link between nature of such changes and animal nervous system typology. Thus, in order, impairments of brain activity after model irradiation compared to such of an interplanetary flight are observed at every level of nervous system structure.

关键词

ionizing radiation, cosmic rays, neurochemical, expression, SNARE, rats

参考

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