THE EVALUATION OF RISK OF DEVELOPMENT AND COURSE OF BRONCHIAL ASTHMA ON THE BASIS OF POLYMORPHISM OF GENE TNFA

封面

如何引用文章

全文:

详细

The bronchial asthma is one of the most widespread multi-factorial diseases developing in interaction of environmental and genetic factors. The purpose of this study was to analyze association of polymorphism of gene TNFA with risk of development of bronchial asthma considering clinical form of disease. The polymerase chain reaction technique was applied to analyze polymorphic locus rs1800629 of gene TNFA in patients with bronchial asthma (n=133) and control group (n=195). The analysis of rate of polymorphism of gene TNFA established reliable increasing of rate of allele A in group of patients with bronchial asthma as compared with control sample. According the coefficient of chances ratio, the risk of development of bronchial asthma if there is allele A of polymorphic locus rs1800629 of gene TNFA increases more than twice (OR=2,53; 95% CI 1,45-4,43). At that, various firms of bronchial asthma have specific features in distribution of rates of genotypes of polymorphic locus rs1800629 of gene TNFA. It is demonstrated that among agents of genotypes GA of polymorphic modification of rs1800629 of gene TNFA patients with mixed form of bronchial asthma were found more frequently than among agents of genotypes GG. The obtained results provide ground to suppose that polymorphic modification of rs1800629 of gene TNFA shows certain damaging effect under various clinical forms of bronchial asthma.

作者简介

G. Mukhammadieva

Ufa Research Institute of Labor and Human Ecology

编辑信件的主要联系方式.
Email: ufniimt@mail.r
俄罗斯联邦

T. Kutlina

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
俄罗斯联邦

D. Karimov

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
俄罗斯联邦

Ya. Valova

Ufa Research Institute of Labor and Human Ecology; Bashkir State University

Email: noemail@neicon.ru
俄罗斯联邦

P. Serebryakov

The F.F. Erisman Federal Research Сenter of Hygiene

Email: noemail@neicon.ru
俄罗斯联邦

A. Melent’Ev

The F.F. Erisman Federal Research Сenter of Hygiene

Email: noemail@neicon.ru
俄罗斯联邦

A. Bakirov

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
俄罗斯联邦

A. Shagalina

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
俄罗斯联邦

E. Idiyatullina

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
俄罗斯联邦

参考

  1. Флетчер Р., Флетчер С., Вагнер Э. Клиническая эпидемиология. Основы доказательной медицины. М.: МедиаСфера; 1998.
  2. Jakeways N., McKeever T., Lewis S.A., Weiss S.T., Britton J. Relationship between FEVi reduction and respiratory symptoms in the general population. Eur. Respir. J. 2003; 21(4): 658-63.
  3. Jindal S.K. Genetic basis of asthma. Indian J. Med. Res. 2015; 142(6): 640-3.
  4. Bin L., Leung D.Y. Genetic and epigenetic studies of atopic dermatitis. Allergy Asthma Clin. Immunol. 2016; 12: 52.
  5. Panek M., Pietras T., Fabijan A., Miłanowski M., Wieteska L., Górski P. et al. Effect of glucocorticoid receptor gene polymorphisms on asthma phenotypes. Exp Ther Med. 2013; 5(2): 572-80.
  6. Wilson A.G., Symons J.A., McDowell T.L., McDevitt H.O., Duff G.W. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc. Natl. Acad. Sci. USA. 1997; 94(7): 3195-9.
  7. Zhang S., Wang C., Xi B., Li X. Association between the tumour necrosis factor-α-308G/A polymorphism and chronic obstructive pulmonary disease: an update. Respirology. 2011; 16(1): 107-15.
  8. Yin Y.W., Wu Z.G., Sun Q.Q., Hu A.M., Wang Q., Liu H.L. Associations between tumor necrosis factor alpha gene -238 G/A and -308 G/A polymorphisms and the risk of pneumoconiosis: update of a meta-analysis. Curr. Med. Res. Opin. 2013; 29(11): 1435-42.
  9. Mabunda N., Alvarado-Arnez L.E., Vubil A., Mariamo A., Pacheco A.G., Jani I.V., Moraes M.O. Gene polymorphisms in patients with pulmonary tuberculosis from Mozambique. Mol. Biol. Rep. 2015; 42(1): 71-6.
  10. Zheng B.Q., Wang G.L., Yang S., Lu Y.Q., Liu R.J., Li Y. Study of genetic susceptibility in 198 children with asthma. Zhongguo Dang Dai Er Ke Za Zhi. 2012; 14(11): 811-4.
  11. Shaker O.G., Sadik N.A., El-Hamid N.A. Impact of single nucleotide polymorphism in tumor necrosis factor-alpha gene 308G/A in Egyptian asthmatic children and wheezing infants. Hum. Immunol. 2013; 74(6): 796-802.
  12. Buckova D., Izakovicova Holla L., Vasku A., Znojil V., Vacha J. Lack of association between atopic asthma and the tumor necrosis factor (alpha)-308 gene polymorphism in a Czech population. J. Invest. Allergol. Clin. Immunol. 2002; 12(3): 192-7.
  13. Kamali-Sarvestani E., Ghayomi M.A., Nekoee A. Association of TNF-(alpha)-308 G/A and IL-4-589 C/T gene promoter polymorphisms with asthma susceptibility in the South of Iran. J. Invest. Allergol. Clin. Immunol. 2007; 17(6): 361-6.
  14. Witte J.S., Palmer L.J., O'Connor R.D., Hopkins P.J., Hall J.M. Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. Eur. J. Hum. Genet. 2002; 10(1): 82-5.
  15. Shin H.D., Park B.L., Kim L.H., Jung J.H., Wang H.J., Kim Y.J. et al. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum. Mol. Genet. 2004; 13(4): 397-403.
  16. Sharma S., Sharma A., Kumar S., Sharma S.K., Ghosh B. Association of TNF haplotypes with asthma, serum IgE levels, and correlation with serum TNF-alpha levels. Am. J. Respir. Cell. Mol. Biol. 2006; 35(4): 488-95.
  17. Ricciardolo F.L., Sorbello V., Silvestri M., Giacomelli M., Debenedetti V.M., Malerba M. et al. TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians. Int. J. Immunopathol. Pharmacol. 2013; 26(1): 75-84.
  18. Yang G., Chen J., Xu F., Bao Z., Yao Y., Zhou J. Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis. PLoS One. 2014; 9(6): e99962.
  19. Sandford A.J., Chan H.W., Wong G.W., Lai C.K., Chan-Yeung M. Candidate genetic polymorphisms for asthma in Chinese schoolchildren from Hong Kong. Int. J. Tuberc. Lung. Dis. 2004; 8(5): 519-27.
  20. Останкова Ю.В., Иващенко Т.Э., Келембет Н.А., Лаврова О.В., Гембицкая Т.Е., Баранов В.С. Комплексный анализ полиморфизма генов NOS1, NOS3, TNFA у больных бронхиальной астмой. Молекул. мед. 2008; (5): 24-9.
  21. Kim H.B., Kang M.J., Lee S.Y., Jin H.S., Kim J.H., Kim B.S. et al. Combined effect of tumour necrosis factor-Alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma. Clin. Exp. Allergy. 2008; 38(5): 774-80.
  22. Holloway J.W., Yang I.A., Holgate S.T. Genetics of allergic disease. J. Allergy Clin. Immunol. 2010; 125(2, Suppl. 2): S81-94.
  23. Michel S., Liang L., Depner M. et al. Unifying candidate gene and GWAS approaches in asthma. PLoS One. 2010; 5(11): e13894.
  24. Yucesoy B., Kashon M.L., Johnson V.J., Lummus Z.L., Fluharty K., Gautrin D. et al. Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. J. Immunotoxicol. 2016; 13(1): 119-26.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Mukhammadieva G.F., Kutlina T.G., Karimov D.O., Valova Y.V., Serebryakov P.V., Melent’Ev A.V., Bakirov A.B., Shagalina A.U., Idiyatullina E.F., 2020

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ:  ПИ № ФС77-50668 от 13.07.2012 г.