Effect of gamma-irradiation of papain on physicochemical properties of its aqueous solutions

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The effect of γ-irradiation of papain with doses from 30 to 700 kGy on light absorption in the UV and visible regions, isoelectric state, viscosity, surface tension and electrical conductivity of its aqueous solutions has been studied. It is shown that the increase of irradiation dose of papain on the one hand is accompanied by the increase of absorption in the UV and visible regions, as well as by the increase of electrical conductivity, on the other hand, the increase of irradiation dose of papain is accompanied by the decrease of viscosity and surface tension of its solutions. The main reasons for such changes are the destruction of peptide bonds in papain during radiolysis and reduction of its molecular weight, radiation-induced oxidation of amino acid residues and formation of carbonyl derivatives, as well as the formation and accumulation in papain macromolecules of various terminal primary amino groups carrying a positive charge.

作者简介

A. Gataullin

Kazan National Research Technological University

Email: sadush@icp.ac.ru
Kazan, 420015 Russia

S. Bogdanova

Kazan National Research Technological University

Email: sadush@icp.ac.ru
Kazan, 420015 Russia

A. Shevyakova

Kazan National Research Technological University

Email: sadush@icp.ac.ru
Kazan, 420015 Russia

S. Demidov

Federal Research Center for Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences

Chernogolovka, 142432 Russia

S. Allayarov

Federal Research Center for Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences

Email: sadush@icp.ac.ru
Chernogolovka, 142432 Russia

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